Posted by ""Ali Bastani"" <asb@homer.att.com>
Dear Colleagues,
Is there, at any level, a system dynamics model of human body structure and functions?
Regards,
Ali
__________________________________
Ali Bastani, Ph.D.
Principal Member of Technical Staff
AT&T Labs.
Florham Park, New Jersey
Posted by ""Ali Bastani"" <asb@homer.att.com> posting date Mon, 15 Jan 2007 12:26:29 -0500 _______________________________________________
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""Ali Bastani"" <asb@homer.at
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""Jim Thompson"" <james.thomp
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Posted by ""Jim Thompson"" <james.thompson@strath.ac.uk>
Dr. Bastani askes, "" Is there, at any level, a system dynamics model of human body structure and functions?""
The Archimedes model at Kaiser Permanente is developed with significant anatomy, physiology and pathology feedbacks in its structure.
http://www.archimedesmodel.com/archimedes.htm Whether it is a system dynamics model is in the eyes of the beholder.
Jim Thompson
james.thompson@strath.ac.uk
Posted by ""Jim Thompson"" <james.thompson@strath.ac.uk> posting date Tue, 16 Jan 2007 14:18:47 -0500 _______________________________________________
Dr. Bastani askes, "" Is there, at any level, a system dynamics model of human body structure and functions?""
The Archimedes model at Kaiser Permanente is developed with significant anatomy, physiology and pathology feedbacks in its structure.
http://www.archimedesmodel.com/archimedes.htm Whether it is a system dynamics model is in the eyes of the beholder.
Jim Thompson
james.thompson@strath.ac.uk
Posted by ""Jim Thompson"" <james.thompson@strath.ac.uk> posting date Tue, 16 Jan 2007 14:18:47 -0500 _______________________________________________
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<D.C.Lane@lse.ac.uk>
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Posted by <D.C.Lane@lse.ac.uk>
The paper ""A Dynamic Simulator for the Management of Disorders of the Body Water Metabolism"" by Özge Karanfil won the Dana Meadows Award at the
2006 conference An excellent paper on this subject. See
http://www.systemdynamics.org/conferenc ... /index.htm
D. C. Lane BSc MSc DPhil FORS
Reader in Management Science
London School of Economics and Political Science Houghton Street, LONDON WC2 2AE, Britain Posted by <D.C.Lane@lse.ac.uk> posting date Tue, 16 Jan 2007 12:42:16 -0000 _______________________________________________
The paper ""A Dynamic Simulator for the Management of Disorders of the Body Water Metabolism"" by Özge Karanfil won the Dana Meadows Award at the
2006 conference An excellent paper on this subject. See
http://www.systemdynamics.org/conferenc ... /index.htm
D. C. Lane BSc MSc DPhil FORS
Reader in Management Science
London School of Economics and Political Science Houghton Street, LONDON WC2 2AE, Britain Posted by <D.C.Lane@lse.ac.uk> posting date Tue, 16 Jan 2007 12:42:16 -0000 _______________________________________________
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""Alan Graham"" <Alan.Graham@
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Posted by ""Alan Graham"" <Alan.Graham@paconsulting.com>
Hi Ali,
There are many models of physiological and metabolic systems, a few explicitly by System Dynamicists, and many many more that are dynamic models differing mostly in nomenclature from ""standard SD"".
System Dynamics modeling of medical systems started in the 1970s with Richard O. Foster's MIT thesis on glucose regulation and diabetes, and my MIT thesis on endocrine regulation of the onset of puberty. Both of these are available online through MIT. Erik Mosekilde has done continuing work on dynamics of nephrons in the kidneys, at least one publication appearing in the System Dynamics Review. PA Consulting did an extensive model of immune response, capable of recreating viral and bacterial attack, and onset and treatment of rheumatoid arthritis. (Due to commercial circumstances, this work was never published.) Jack Homer did an excellent ISDC conference paper on drug resistance adaptation in bacteria. Doubtless I'm not recalling or missing several.
Beyond these, a significant portion of metabolic and physiological models in the medical literature are based on rather simplified (by SD
standards) differential equations. Given that such models aren't using the SD skills in understanding decision-making, it's difficult to say that they're definitely not SD models. (Editorial: Of course, many such models are academic, and have the only apparent usefulness or purpose of getting published, but truth be told, we in SD, at least in the publications side, aren't entirely free of that particular lacuna.)
Beyond these, there's a loosely-organized movement called The Physiome Project, whose aim is to model the entire body, in the same way that the Genome Project mapped the entire human genome. Google it.
Beyond these, there's a newer movement called Systems Biology, whose goal is more comprehensive examination of most traditional topics. And guess what, many of the models are remarkably System Dynamics like.
Bottom line is, there's a lot done and being done with philosophy, aims and tools very much like SD, and a small fraction of that is ""SD-branded"".
Cheers,
Alan
Alan K. Graham, PhD
Federal and Defense Services
PA Consulting Group
Posted by ""Alan Graham"" <Alan.Graham@paconsulting.com> posting date Tue, 16 Jan 2007 12:50:44 -0500 _______________________________________________
Hi Ali,
There are many models of physiological and metabolic systems, a few explicitly by System Dynamicists, and many many more that are dynamic models differing mostly in nomenclature from ""standard SD"".
System Dynamics modeling of medical systems started in the 1970s with Richard O. Foster's MIT thesis on glucose regulation and diabetes, and my MIT thesis on endocrine regulation of the onset of puberty. Both of these are available online through MIT. Erik Mosekilde has done continuing work on dynamics of nephrons in the kidneys, at least one publication appearing in the System Dynamics Review. PA Consulting did an extensive model of immune response, capable of recreating viral and bacterial attack, and onset and treatment of rheumatoid arthritis. (Due to commercial circumstances, this work was never published.) Jack Homer did an excellent ISDC conference paper on drug resistance adaptation in bacteria. Doubtless I'm not recalling or missing several.
Beyond these, a significant portion of metabolic and physiological models in the medical literature are based on rather simplified (by SD
standards) differential equations. Given that such models aren't using the SD skills in understanding decision-making, it's difficult to say that they're definitely not SD models. (Editorial: Of course, many such models are academic, and have the only apparent usefulness or purpose of getting published, but truth be told, we in SD, at least in the publications side, aren't entirely free of that particular lacuna.)
Beyond these, there's a loosely-organized movement called The Physiome Project, whose aim is to model the entire body, in the same way that the Genome Project mapped the entire human genome. Google it.
Beyond these, there's a newer movement called Systems Biology, whose goal is more comprehensive examination of most traditional topics. And guess what, many of the models are remarkably System Dynamics like.
Bottom line is, there's a lot done and being done with philosophy, aims and tools very much like SD, and a small fraction of that is ""SD-branded"".
Cheers,
Alan
Alan K. Graham, PhD
Federal and Defense Services
PA Consulting Group
Posted by ""Alan Graham"" <Alan.Graham@paconsulting.com> posting date Tue, 16 Jan 2007 12:50:44 -0500 _______________________________________________
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""Geoff McDonnell"" <gmcdonne
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Posted by ""Geoff McDonnell"" <gmcdonne@bigpond.net.au>
Özge has also contributed substantially to provide references in this area at the Health Policy SIG wiki http://www.hpsig.com/index.php?title=Sy ... Physiology
rgds
Geoff McDonnell
Posted by ""Geoff McDonnell"" <gmcdonne@bigpond.net.au> posting date Wed, 17 Jan 2007 23:14:05 +1100 _______________________________________________
Özge has also contributed substantially to provide references in this area at the Health Policy SIG wiki http://www.hpsig.com/index.php?title=Sy ... Physiology
rgds
Geoff McDonnell
Posted by ""Geoff McDonnell"" <gmcdonne@bigpond.net.au> posting date Wed, 17 Jan 2007 23:14:05 +1100 _______________________________________________
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""Abdel-Hamid, Tarek (CIV)"" <
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Posted by ""Abdel-Hamid, Tarek (CIV)"" <tkabdelh@nps.edu>
1. Stella/iThink software comes with a number of example models from a wide range of applications. Included is at least one physiologic model on insulin regulation.
2. The book... Hargrove JL. 1998. Dynamic Modeling in the Health Sciences.
Springer: New York, includes many small physiologic models. Use them for ideas... and use them carefully. I detected several formulation ""issues""
(the author is not a system dynamicist).
3. A system dynamics model of human metabolism and energy regulation is discussed in: Abdel-Hamid, T.K. Modeling the Dynamics of Human Obesity.
System Dynamics Review, Vol. 18, No. 4, Winter, 2002: 431-471.
Dr. Tarek K. A. Hamid, Professor
Naval Postgraduate School
Posted by ""Abdel-Hamid, Tarek (CIV)"" <tkabdelh@nps.edu> posting date Wed, 17 Jan 2007 10:27:57 -0800 _______________________________________________
1. Stella/iThink software comes with a number of example models from a wide range of applications. Included is at least one physiologic model on insulin regulation.
2. The book... Hargrove JL. 1998. Dynamic Modeling in the Health Sciences.
Springer: New York, includes many small physiologic models. Use them for ideas... and use them carefully. I detected several formulation ""issues""
(the author is not a system dynamicist).
3. A system dynamics model of human metabolism and energy regulation is discussed in: Abdel-Hamid, T.K. Modeling the Dynamics of Human Obesity.
System Dynamics Review, Vol. 18, No. 4, Winter, 2002: 431-471.
Dr. Tarek K. A. Hamid, Professor
Naval Postgraduate School
Posted by ""Abdel-Hamid, Tarek (CIV)"" <tkabdelh@nps.edu> posting date Wed, 17 Jan 2007 10:27:57 -0800 _______________________________________________
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fadl alakwa <fadlmaster1@yaho
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Posted by fadl alakwa <fadlmaster1@yahoo.com>
there is a good model in this theses
The Metabolic Endocrine Glucose _ Insulin Regulatory System: System
Dynamics Approach”, Systems and Biomedical Engineering Department,
Faculty of Engineering, Cairo University, Cairo, Egypt 2006.
or you can read this paper Wahba, Khaled with Fadl Ahmed and Abdalla
Mohamed, ""Modelling the Glucose Regulatory Feedback System --
Understand the Mechanism Underlying Ultradian Oscillations"" at
http://www.systemdynamics.org/conferences/2006/proceed
regards
Posted by fadl alakwa <fadlmaster1@yahoo.com> posting date Sat, 20 Jan 2007 22:00:13 -0800 (PST) _______________________________________________
there is a good model in this theses
The Metabolic Endocrine Glucose _ Insulin Regulatory System: System
Dynamics Approach”, Systems and Biomedical Engineering Department,
Faculty of Engineering, Cairo University, Cairo, Egypt 2006.
or you can read this paper Wahba, Khaled with Fadl Ahmed and Abdalla
Mohamed, ""Modelling the Glucose Regulatory Feedback System --
Understand the Mechanism Underlying Ultradian Oscillations"" at
http://www.systemdynamics.org/conferences/2006/proceed
regards
Posted by fadl alakwa <fadlmaster1@yahoo.com> posting date Sat, 20 Jan 2007 22:00:13 -0800 (PST) _______________________________________________