QUERY Physiological Diabetes Models
Posted: Tue Jul 01, 2008 7:51 am
Posted by j-d <jaideep@optimlator.com>
I am wondering if there is/are publicly available paper/s and/or
system dynamics model/s simulating the role of various hormones
(insulin, glucagon, etc.) in diabetes, for understanding and
management of the disease.
I vaguely remember there being something in SDR a few years ago. Most
of the studies seem to be in the area of public policy as it relates
to spread of diabetes and/or other diseases. My interest is in looking
at models simulating the internal mechanisms (inside the body). From
my little study of the endocrine system, it has all the patterns of a
nonlinear system with delays, unintended effects, limits,
unpredictable behavior and so on (in other words, a complex system).
The same patterns are obvious when one looks at various diets in the
prevention and/or management of obesity. Just like climate change or
Limits to Growth models, management of these complex systems is tricky
- for example, policy change in one area (various diet regimens, or
various hormone administrations through diet modifications or
injections) has possible good or bad effects elsewhere (this is
familiar to members on this list, especially for those who have played
with Beer Game and LTG models).
I would be surprised if there are no such models - human body, as it
is managed within some strict ranges (temperature, hormones, glucose,
and so on) can be modeled as a structured system. There is a huge
amount of medical data available. This will require an interface
between endocrinologists and system dynamics modelers - if it has not
already been done. Perfect project for an interface between SD and
medical sciences - part of a Masters or a Ph. D. project maybe!!
Would it be possible for someone to provide references or, better
still, the model/s itself?
Much thanks
Jaideep
Jaideep Mukherjee, Ph. D.
Posted by j-d <jaideep@optimlator.com>
posting date Mon, 30 Jun 2008 09:43:46 -0500
_______________________________________________
I am wondering if there is/are publicly available paper/s and/or
system dynamics model/s simulating the role of various hormones
(insulin, glucagon, etc.) in diabetes, for understanding and
management of the disease.
I vaguely remember there being something in SDR a few years ago. Most
of the studies seem to be in the area of public policy as it relates
to spread of diabetes and/or other diseases. My interest is in looking
at models simulating the internal mechanisms (inside the body). From
my little study of the endocrine system, it has all the patterns of a
nonlinear system with delays, unintended effects, limits,
unpredictable behavior and so on (in other words, a complex system).
The same patterns are obvious when one looks at various diets in the
prevention and/or management of obesity. Just like climate change or
Limits to Growth models, management of these complex systems is tricky
- for example, policy change in one area (various diet regimens, or
various hormone administrations through diet modifications or
injections) has possible good or bad effects elsewhere (this is
familiar to members on this list, especially for those who have played
with Beer Game and LTG models).
I would be surprised if there are no such models - human body, as it
is managed within some strict ranges (temperature, hormones, glucose,
and so on) can be modeled as a structured system. There is a huge
amount of medical data available. This will require an interface
between endocrinologists and system dynamics modelers - if it has not
already been done. Perfect project for an interface between SD and
medical sciences - part of a Masters or a Ph. D. project maybe!!
Would it be possible for someone to provide references or, better
still, the model/s itself?
Much thanks
Jaideep
Jaideep Mukherjee, Ph. D.
Posted by j-d <jaideep@optimlator.com>
posting date Mon, 30 Jun 2008 09:43:46 -0500
_______________________________________________